Effects of eliminating a disulfide bridge within domain II of Pseudomonas aeruginosa exotoxin A
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منابع مشابه
Effects of eliminating a disulfide bridge within domain II of Pseudomonas aeruginosa exotoxin A.
Cysteines 265 and 287 of Pseudomonas aeruginosa exotoxin A (ETA) were substituted by serine, thereby eliminating a disulfide bridge within domain II, the putative membrane insertion-translocation domain. Purified mutant toxin was 80-fold less toxic for mouse L cells than was wild-type ETA while retaining the same specific activity in the ADP-ribosyltransferase reaction as did wild-type toxin. B...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1989
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.57.7.1873-1878.1989